New therapy could save millions from going blind

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A NEW gene therapy being developed at ANU will help people at risk of dry age-related macular degeneration (AMD) and could potentially save millions of people from going blind.

Dr Joshua Chu-Tan

Dry AMD, a common disorder caused by damage to the macula (the part of the eye that is responsible for our sharpest vision) can take years for signs of dry AMD to be found in the eye and often, by the time it’s diagnosed, the disease is irreversible.

Dr Joshua Chu-Tan, from The John Curtin School of Medical Research, is developing a new eye injection that has the potential to stop the progression of the disease.

“AMD is the leading cause of blindness and the most common form of the disease, dry AMD, has no cure,” Dr Chu-Tan says.

It is estimated that by 2020, there will be 196 million people living with AMD worldwide.

“If doctors find there are traces of dry AMD advancing in your retina there is nothing they can do for you – your sight can’t be saved,” he says.

But, Dr Chu-Tan has been researching preventative gene therapy using tiny molecules called microRNA that he describes as “the gods of gene regulation”.

He is using microRNA to target the causes of AMD.

“We know inflammatory pathways plays a major role in AMD and tiny molecules called microRNA can fight them in a multi-pronged way,” he says.

“When we inject anti-inflammatory mircoRNA into the eye we see a decrease in genes responsible for inflammation and cell death, as well as a slowing in the damage progression of the retina.

“We are not just cutting the weed when it grows, we are trying to pull the weed out by its roots.”

Dr Chu-Tan says a specific microRNA, microRNA-124, has great promise as a preventative treatment for AMD as an alternative to the eye injections offered now.

“We think we have found a major player in slowing the disease with microRNA-124,” he says.

“By injecting a cocktail of these molecules we think we can slow the progression of this disease and hopefully halt vision loss.

“When we compare an AMD patient to a healthy individual, the healthy individual has a lot of this microRNA-124 all over their retina, whereas in an AMD patient there is none.

“However in an AMD patient’s periphery of the retina, where there is no damage, there is microRNA-124.”

Dr Joshua Chu-Tan will be presenting his research at a TEDx talk in New Zealand on August 25

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