Health risks of nicotine cast doubt on ‘safer’ e-cigarette

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By Ross MacKenzie; Benjamin Hawkins, London School of Hygiene & Tropical Medicine, and Thomas Novotny, San Diego State University

BRITISH American Tobacco Australia has lobbied Australia’s Therapeutic Goods Administration to have electronic cigarettes (e-cigarettes) classified as a harm-reduction pharmaceutical product. If successful, this would allow media advertising for e-cigarettes similar to that seen for nicotine replacement products.

On Friday the ABC revealed the TGA had mistakenly approved an e-cigarette device as a “quit smoking aid”. The product remained on the Australian Register of Therapeutic Goods for two months before the TGA realised the error and began a review of the product.

E-cigarettes, of course, are battery-operated devices that vapourise fluids so they can be inhaled deep into the lungs. The nicotine enters the arterial blood and goes straight to the brain, much like the nicotine from regular cigarettes.

There is no evidence e-cigarettes help smokers quit. Nor are they harmless; even without the smoke, nicotine poses a number of health risks.

E-cigarettes should not be sold in Australia, either as a therapy or a consumer product.

Not a tool to help smokers quit

Proponents of e-cigarettes argue the product represents an important advance in harm reduction, so Australia’s ban on the sale and promotion of e-cigarettes is “counterproductive”. Because the vapour contains lower levels of the chemicals found in cigarette smoke, they argue it poses less of a risk to users and bystanders.

They also argue e-cigarettes may be more effective than unassisted quitting or nicotine-replacement therapies such as patches, gum or inhaler.

Those urging a more cautious approach, as we do, point to the near-complete absence of any rigorous analysis of their safety, usage patterns and effectiveness in helping smokers quit.

E-cigarette manufacturers produce a variety of sweet-flavoured vapourising ‘juices’.

Opponents are also concerned about the appeal of e-cigarettes to non-smokers, particularly adolescents and children. They may be attracted by the commonly added range of candy, fruit and other flavourings.

These concerns are exacerbated by the tobacco industry’s determined entry into the e-cigarette market in recent years. Regulatory uncertainty in the United Kingdom and United States, for instance, has allowed the industry to aggressively promote e-cigarettes that are designed and packaged to look like traditional products in markets where cigarette advertising has been long prohibited.

Promotion and the increasing use of e-cigarettes in public spaces threaten to undo decades of progress in tobacco control. This also represents an important strategic opportunity for the tobacco industry to circumnavigate advertising restrictions at precisely the moment when a number of countries are removing package branding and point-of-sale displays.

Health risks of nicotine

Curiously, the key issue of health risks associated with nicotine has been largely marginalised in the e-cigarette debate. In a letter to World Health Organisation Director-General Margaret Chan earlier this year, proponents of e-cigarette stated: “We have known for years that people ‘smoke for the nicotine, but die from the smoke’.“ But the health risks extend beyond the smoke.

A recent article in Nature Reviews Cancer suggests nicotine is genotoxic (capable of damaging DNA and leading to cancer), promotes tumours and is linked to the onset and growth of head and neck, gastric, pancreatic, gallbladder, liver, colon, breast, cervical, urinary bladder and kidney cancers, as well as small-cell and other lung carcinomas.

There are also potential implications for immune response. Nicotine is an immunomodulator, an agent that can alter the body’s ability to produce antibodies. This can impact a range of cells involved in inflammatory processes, including those in the lung and vascular system.

This may have important implications for those infected with tuberculosis and other bacterial diseases. It could also have particular implications for those with compromised immune systems. Patients with HIV/AIDS, for instance, are more vulnerable to tuberculosis infection.

Nicotine can impact on fetal brain development and cause acute nicotine toxicity. The number of cases of nicotine poisoning caused by swallowing e-cigarette liquids containing nicotine has risen sharply in the US and UK.

Recent research on second-hand exposure indicates that while vapour from e-cigarettes is less harmful than cigarette smoke, it can expose bystanders to nicotine as well as other potentially toxic elements.

Time to re-frame the debate

Disagreement on the potential health impacts of e-cigarettes has divided the tobacco control community unlike any other recent topic, except perhaps for the “safer” cigarette notions of low-tar and light. Unregulated advertising of these no-less-harmful products allowed them to flourish in a sea of unsubstantiated health claims.

Nicotine is potentially addictive regardless of how it is consumed. This raises questions about the logic and morality of licensing new delivery systems as consumer products. Further, focusing on its addictive properties has arguably contributed to public misconceptions about nicotine’s links to carcinogenesis and other health risks.

We need a greater understanding of the health effects of nicotine – and e-cigarettes in general – to inform current regulatory debates at the national and global level. Until then, there is enough evidence to support a precautionary approach to e-cigarettes that puts public health concerns ahead of the commercial freedoms of the tobacco industry and other e-cigarette manufacturers.

The Conversation

Ross MacKenzie has received research funding from the Rockefeller Foundation, the National Institutes of Health, and the Cancer Council NSW.

Benjamin Hawkins receives funding from the NIH.

Thomas Novotny receives funding from The National Institutes of Health, the SeriousFun Foundation, and the University of California Tobacco Related Disease Research Program. He is the CEO of the Cigarettee Butt Pollution Project, a 501c3 Tax-exempt Organization registered in California..

This article was originally published on The Conversation.
Read the original article.

[Photo by Jon Williams, attribution licence]

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  1. There is no doubt that nicotine is addictive – harmful and needs control. Should there be educational campaigne that raises awareness regarding effects of nicotine and how e cigarette can potentially increase its intake so people know what they are doing. There are controversial arguments which is so confusing to most people. Hope that we don’t forget tobacco smoke is already a proven killer which is so readily available anywhere (actually deserves banning completely) and only focus on petential harm e cigarette can cause. E-cigarettes are not harmless – no study claims that – Many do claim it does not contain many of the harmful chemicals found in tobacco. There should be strategy in place to avoid normalizing e cigarette but without disadvantaging chronic tobacco smokers wanting to give alternatives a try.

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